Summary of the April 16, 2013 issue, including articles on patient-centered decision making, use of computer-aided detection in mammography, computed tomography screening for osteoporosis, risk prediction models for chronic kidney disease, and medications to reduce risk for breast cancer, as well as an Update in General Internal Medicine and a position paper from the American College of Physicians and the Federation of State Medical Boards on online medical professionalism and the patient-physician relationship.