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Straight from a Scientist Medical Research Education and Discussion Podcast

We want your updates on today's scientific research directly from the source: straight from the scientist working hard to make new discoveries about our world. We’re here to help you learn the what, the why, and the how of the research we produce every day. Informal interviews probe deep into how science is done, and why the how matters when it's time to interpret the results. Roundtable discussions introduce you to hot new fields of study or investigate the darker sides of science. To keep your science fresh, subscribe below or follow us on social media @straightfromascientist on instagram and twitter

Risk and Reward in Alzheimer's disease

Published: Dec. 13, 2023, noon
Duration: 47 minutes 9 seconds

Listed in: Science

Deep Brain Degeneration in Alzheimers Disease with Dr. Lea Grinberg & Research Team

Published: May 30, 2023, noon
Duration: 2 hours 5 minutes 48 seconds

Listed in: Science

Season 2 Episode 1: Neural Networks on Noradrenaline

Published: Jan. 18, 2022, 3:38 p.m.
Duration: 1 hour 20 minutes 58 seconds

Listed in: Science

Ep56- Unlocking Genetic Regulation

Published: April 3, 2020, 1:49 p.m.
Duration: 50 minutes 47 seconds

Listed in: Science

Ep55- Fetal Vulnerability to Cannabis and Alcohol

Published: March 12, 2020, 3:08 p.m.
Duration: 53 minutes 54 seconds

Listed in: Science

E54- Supermassive Black Holes in Dwarf Galaxies

Published: Feb. 18, 2020, 12:39 p.m.
Duration: 1 hour 11 minutes 8 seconds

Listed in: Science

Ep 53 - How Bacteria Survive the Immune System

Published: Jan. 5, 2020, 2:52 p.m.
Duration: 39 minutes 11 seconds

Listed in: Science

Ep 52 - Diabetes and Placental Epigenetics

Published: Dec. 1, 2019, 3:56 p.m.
Duration: 51 minutes 56 seconds

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Ep. 51 New Cancer Therapies & Targeting Cancer Biology

Published: Nov. 5, 2019, 4 p.m.
Duration: 1 hour 30 minutes 38 seconds

Join Lebaron (Lee) Agostini and Connor Wander in our FIRST VIDEO episode! This episode is all about Cancer Biology. Lee studies experimental cancer therapies for pancreatic cancer. New cancer therapies called combination or synergystic cancer therapies use multiple drug types to shut down, corner, and eliminate cancer cells in the body.

The full video version of this episode is available on Nov 5th at 7PM EST\\xa0! Head on over to our YouTube Channel and check it out there! Also streaming (audio only) on all the usual platforms.

Further information

Here\'s a recent paper from Lee and his lab at Jefferson University: https://cancerres.aacrjournals.org/content/early/2019/07/04/0008-5472.CAN-18-3645

Any other questions for Lee? Ask him on Instagram or LinkedIn

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Ep.50 - Alzheimer's disease FAQ

Published: Oct. 2, 2019, 8:14 p.m.
Duration: 1 hour 8 minutes 43 seconds

Listed in: Science

Ep. 49 - Alzheimer's disease overview with Konner Blunt

Published: Sept. 8, 2019, 3:17 p.m.
Duration: 1 hour 48 minutes 31 seconds

Listed in: Science

Ep. 48- Are Herbal Supplements Effective? Using Modern Science to Investigate Ancient Medicines with Tayler Catherine

Published: June 15, 2019, 9:56 a.m.
Duration: 51 minutes 34 seconds

Tayler is a PhD candidate in the College of Veterinary Medicine at Murdoch University in Perth, Western Australia. Her research focuses on the pharmacology and toxicology of supposed \\u2018fertility-boosting\\u2019 herbal supplements on sperm cells, using flow cytometry to elucidate their effects at a cellular level. She is also a science communicator in her spare time, and posts regular pharmacology-based series online. You can find her on Instagram at @taylercatherine

Link to a good general review on oxidative stress: https://www.nature.com/articles/35041687
Link to a review of herbal medicine safety issues: https://www.mja.com.au/journal/2017/206/2/what-risks-do-herbal-products-pose-australian-community

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Ep. 47- Genetic Big data for Personalized Medicine with Sean Jackewicz

Published: June 15, 2019, 9:55 a.m.
Duration: 51 minutes 44 seconds

Listed in: Science

Ep. 46- Stimulate Your Brain for Better Mental Health

Published: May 31, 2019, 1:38 p.m.
Duration: 41 minutes 49 seconds

Alzheimer\'s disease is a terrifying neurodegenerative disorder characterized by impaired memory, cognitive deficits, and neuronal loss. With few treatments and no cure after decades of research, scientists are starting to think outside the box for better ways to ward off Alzheimer\'s disease. In this episode, we discuss the links between mental health and neurodegenerative disorders like Alzheimer\'s, and how common strategies for better mental health have great promise for Alzheimer\'s disease treatment. In general, the best protective strategies for Alzheimer\'s disease are things that improve mental health, such as trying new things and staying active.

In this episode, we talk with Dr. Harry Steinbusch from Maastricht University. Dr. Steinbusch has a wide array of research interests centered mostly around how everyday activities might help protect against neurodegenerative disorders, and how genetic modifications like epigenetics are important in disorders like Alzheimer\'s disease. We also talk about how Dr. Steinbusch runs his lab from all over the world, and his founding of the AD Fast Track conference

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Some actionable tips for better mental health:

Use it or lose it - an active brain is a healthy brain! Learning new things and traveling to new places stimulates adult neurogenesis, the birth and development of new neurons in the brain
Exercise, particularly group exercise, was found to be most beneficial
Learning more than one language is also linked to better mental health

Citations and further reading:

Andrew Crowther, soon to be PhD from the Song Lab talks with Connor Wander about his research- serotonin and adult neurogenesis.
Epigenetic changes in Alzheimer\'s disease neurons
Some other great places to start for exercise induced neurogenesis.

This episode marks the final part of the AD Fast Track series. Check out all previous episodes, and stay tuned for more some summary episodes on Alzheimer\'s disease.

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Ep. 45: Applications and Limitations of GWAS with Dr. Liz Tunbridge

Published: April 21, 2019, 12:02 a.m.
Duration: 23 minutes 4 seconds

Genome-wide association studies, or GWAS, are very helpful in telling researchers where to focus their attention. They point out genetic linkers that have the potential to be used as medicines or diagnostics. GWAS identify genes or clusters of genes associated with greater risk for diseases and disorders.

But GWAS aren\'t a silver bullet...

Dr. Liz Tunbridge studies genetic risk factors for various psychiatric disorders. She has noted that while GWAS are very useful, they have many limitations, and the interpretations of such studies can be very complicated. Listen in to learn more about the challenges of turning this statistical information into something tangible and the complex therapeutic impacts of gene families.

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About Dr. Tunbridge

Dr. Elizabeth "Liz" Tunbridge is an Associate Professor at Oxford University. Her research focuses on how individual genetic variants change brain function in psychiatric disorders, with the hope that understanding this can lead to better treatments for patients.

Dr. Tunbridge is very active on Twitter!

Check out her TED Talk titled "Would there be mental illness in a utopia?"

Dr. Tunbridge is also a writer for The Conversation.

Learn more about her research here.

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More Information

This episode features was recorded in San Diego, CA, where Connor Wander attended the BrightFocus Alzheimer\\u2019s Disease Fast Track conference, followed by the Society for Neuroscience annual meeting. The Society for Neuroscience (SfN) is a well-known conference, drawing 28 thousand people annually.

Any other questions?\\xa0\\xa0Let us know!\\xa0 We appreciate your feedback.

You can now support the podcast at\\xa0https://www.patreon.com/sfspodcast.\\xa0 Many thanks to our past and present supporters!\\xa0

Thanks to\\xa0Plant Warrior\\xa0for their support.\\xa0 Use discount code SFS10 at checkout for 10% off your purchase of plant-based protein.

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Ep. 44: Sex Differences in Alzheimer's Disease with Dr. Roberta Diaz Brinton and Connor Wander

Published: April 9, 2019, 2:43 a.m.
Duration: 28 minutes 25 seconds

Women are almost twice as likely to develop Alzheimer\'s disease as men. However, this is NOT because they live longer. When we look into the aging brain, males and females experience different timelines. The molecular underpinnings of these sex differences could make a huge impact on our understanding of Alzheimer\'s disease. Dr. Roberta Diaz Brinton is spearheading research into sex differences in Alzheimer\'s disease. She works to discover how to protect the aging female brain from these increased risk factors.

This episode features another throwback recorded in San Diego, CA, where Connor Wander attended the BrightFocus Alzheimer\'s Disease Fast Track conference, followed by the Society for Neuroscience annual meeting.

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About Dr. Brinton

Dr. Roberta Diaz Brinton leads the Center for Innovation in Brain Science at the University of Arizona that studies diseases of aging, Alzheimer\\u2019s, Multiple Sclerosis, Parkinson\\u2019s and ALS. Dr. Brinton is an internationally recognized expert in the systems biology of Alzheimer\\u2019s disease. She is developing the first regenerative therapeutic to regenerate the degenerated brain. Her analysis focuses on the brain at greatest risk for Alzheimer\\u2019s: the aging female brain. Her findings show that the sex difference in Alzheimer\\u2019s disease is not because women live longer than men, as commonly thought, but rather because the disease starts earlier in the female brain. Her insights into these key transition states of the aging brain provide therapeutic opportunities to prevent, delay, and treat neurodegenerative disease.

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More Information

Read more about Dr. Roberta Diaz Brinton\'s research and scholarship.

Learn more on the Brinton Lab Website.

The\\xa0Society for Neuroscience (SfN) is a well-known conference, drawing 28 thousand people annually. In contrast, AD Fast Track is a much smaller conference put on by BrightFocus, a foundation built to support AD and glaucoma research and awareness. Many of the speakers at the event were directly supported by BrightFocus (Lamb, Brinton, Head, Grinberg).

Alzheimer\'s disease research is reinventing itself in the wake of past failures. New understandings of disease complexity, paired with recent advances in technology and a renewed surge in funding for research fuels new hope for a cure or treatment. Yet we aren\'t putting all our eggs in one basket. This series explores Alzheimer\'s disease research and the variety of research strategies with the common goal of curing Alzheimer\'s disease.

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Any other questions?\\xa0\\xa0Let us know!\\xa0 We appreciate your feedback.

You can now support the podcast at\\xa0https://www.patreon.com/sfspodcast.\\xa0 Many thanks to our past and present supporters!\\xa0

Thanks to\\xa0Plant Warrior\\xa0for their support.\\xa0 Use discount code SFS10 at checkout for 10% off your purchase of plant-based protein.

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Ep. 43: Down Syndrome and Alzheimer's Disease with Dr. Elizabeth Head and Connor Wander

Published: March 27, 2019, 3:06 p.m.
Duration: 13 minutes 55 seconds

This week\'s episode features another throwback recorded in San Diego, CA, where Connor Wander attended the BrightFocus Alzheimer\'s Disease Fast Track conference, followed by the Society for Neuroscience annual meeting. We talked with Dr. Elizabeth Head, who studies the link between Down Syndrome and Alzheimer\'s disease with the hopes of improving lives for both patient classes. Listen to hear about this super interesting and very promising work!

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About Dr. Elizabeth Head

Dr. Elizabeth Head has recently moved from the University of Kentucky to the University of California, Irvine (UCI) and joined the UCI MIND institute.

Dr. Head has published over 150 peer reviewed papers, over 30 review papers and book chapters and serves as a grant reviewer for the National Institutes on Health. Dr. Head has dedicated over 20 years to the study of aging and Alzheimer\\u2019s disease with a focus on people with Down Syndrome.

Catch Dr. Head\'s livestream where she answers the question: "Are there any promising vaccines for Alzheimer\'s" on May 3rd, 2019.

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More Information

Learn more about The International Brain Bank for Down Syndrome-Related Alzheimer\'s disease\\xa0mentioned in the podcast.

Also watch a presentation by Dr. Head on how to improve quality of life in Down Syndrome and Alzheimer\'s disease.

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The\\xa0Society for Neuroscience (SfN) is a well-known conference, drawing 28 thousand people annually. In contrast, AD Fast Track is a much smaller conference put on by BrightFocus, a foundation built to support AD and glaucoma research and awareness. Many of the speakers at the event were directly supported by BrightFocus (Lamb, Brinton, Head, Grinberg).

Alzheimer\'s disease research is reinventing itself in the wake of past failures. New understandings of disease complexity, paired with recent advances in technology and a renewed surge in funding for research fuels new hope for a cure or treatment. Yet we aren\'t putting all our eggs in one basket. This series explores Alzheimer\'s disease research and the variety of research strategies with the common goal of curing Alzheimer\'s disease.

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Listen to our Alzheimer\'s Fast Track Series

Ep. 39: Alzheimer\\u2019s Disease Research Part I with Drs. Diane Bovenkamp, Frank LaFerla, and Bruce Lamb

Ep. 41: Alzheimer\\u2019s Disease Research roundtable with Drs. Cynthia Lemere, Charles Glabe, and Lea T. Grinberg

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Any other questions?\\xa0\\xa0Let us know!\\xa0 We appreciate your feedback.

You can now support the podcast at\\xa0https://www.patreon.com/sfspodcast.\\xa0 Many thanks to our past and present supporters!\\xa0

Thanks to\\xa0Plant Warrior\\xa0for their support.\\xa0 Use discount code SFS10 at checkout for 10% off your purchase of plant-based protein.

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Ep. 42: Neuronal Apoptosis- The Cautious and the Willing with Dr. Mohanish Deshmukh and Connor Wander

Published: Feb. 10, 2019, 7:01 p.m.
Duration: 50 minutes 51 seconds

This episode is all about neuronal apoptosis.\\xa0 In Dr. Mohanish Deshmukh\'s eyes, some cells are willing to undergo apoptosis, while others are very cautious.\\xa0 Understanding these differences could be the key to understanding, treating, or curing diseases that haunt us in modern times.\\xa0 Research in Dr. Deshmukh\\u2019s lab at the University of North Carolina, Chapel Hill, focuses on pathways for neuronal apoptosis and the ways that survival and death work in different cells.

Apoptosis is programmed cell death.\\xa0 In apoptosis, cells commit "suicide" quietly to minimize inflammation and damage to their neighbors.\\xa0 Apoptosis is a normal and vital process which helps protect us from cancer and other disease states.\\xa0 However, it becomes a problem in neurodegenerative diseases like Alzheimer\'s and ALS.\\xa0 When it comes to apoptosis, neurons are special.\\xa0 Neuronal apoptosis seems to be distinct from other cell types.

Listen in to hear how neurons resist triggers that would kill other cells.\\xa0 Also learn about the difference between apoptosis and necrosis, as well as how that understanding has changed over time.\\xa0 We discuss the importance of synaptic pruning.\\xa0 Finally, we speculate some on the possible presence and effect of bacteria in the brain.

About Dr. Deshmukh

Dr. Mohanish Deshmukh is a Professor of Cell Biology & Physiology and the Neuroscience Center at the University of North Carolina, Chapel Hill.\\xa0

Visit the Deshmukh Lab website to learn more about current research.

Also follow the Deshmukh Lab on Instagram.

More Information

To get a background of apoptosis in other cells, check out\\xa0Episode 23: The Role of Apoptosis with Georgia Smith.\\xa0 She tells us about apoptosis in the context of influenza.

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Any other questions?\\xa0\\xa0Let us know!\\xa0 We appreciate your feedback.

You can now support the podcast at\\xa0https://www.patreon.com/sfspodcast.\\xa0 Many thanks to our past and present supporters!\\xa0

Thanks to\\xa0Plant Warrior\\xa0for their support.\\xa0 Use discount code SFS10 at checkout for 10% off your purchase of plant-based protein.

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Ep. 31: The Microbiota-Gut-Brain Axis: From eubiosis to dysbiosis and back: useful biomarkers for clinical treatment with Miguel Mateas

Published: Aug. 5, 2018, 7:37 p.m.
Duration: 54 minutes 9 seconds

Listed in: Science