Podcasts Science

101 episodes

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Podcasts

Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities

Published: Aug. 14, 2020, 10:01 p.m.
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Listed in: Science

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

Published: Aug. 13, 2020, 10:02 a.m.
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Listed in: Science

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Published: Aug. 13, 2020, 9:01 a.m.
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Listed in: Science

EGFR transactivates RON to drive oncogenic crosstalk

Published: Aug. 12, 2020, 4:03 p.m.
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Targeting KRAS-mutant stomachcolorectal tumours by disrupting the ERK2-p53 complex

Published: Aug. 12, 2020, 4:03 p.m.
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Listed in: Science

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

Published: Aug. 12, 2020, 5:01 a.m.
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Listed in: Science

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells

Published: Aug. 12, 2020, 5:01 a.m.
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Listed in: Science

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

Published: Aug. 12, 2020, 2:05 a.m.
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Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs

Published: Aug. 12, 2020, 2:05 a.m.
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IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

Published: Aug. 12, 2020, 1:01 a.m.
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Listed in: Science

CEBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer

Published: Aug. 11, 2020, 2:02 p.m.
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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Published: Aug. 11, 2020, 2:02 p.m.
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Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma

Published: Aug. 10, 2020, 10:01 p.m.
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Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

Published: Aug. 10, 2020, 10:01 p.m.
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Listed in: Science

An AI-powered blood test to detect cancer using nanoDSF

Published: Aug. 10, 2020, 10:01 p.m.
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Mutant-selective Degradation by BRAF-targeting PROTACs

Published: Aug. 10, 2020, 1:02 p.m.
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Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

Published: Aug. 10, 2020, 1:02 p.m.
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SMARCA4 deficient tumours are vulnerable to KDM6AUTX and KDM6BJMJD3 blockade

Published: Aug. 7, 2020, 7:01 p.m.
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Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model

Published: Aug. 7, 2020, 12:04 a.m.
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Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

Published: Aug. 7, 2020, 12:04 a.m.
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PELP1SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

Published: Aug. 7, 2020, 12:04 a.m.
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The Pancreatic Tumor Microenvironment Buffers Redox Imbalance Imposed by Disrupted Mitochondrial Metabolism

Published: Aug. 7, 2020, 12:04 a.m.
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Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Published: Aug. 6, 2020, 10:01 p.m.
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Listed in: Science

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

Published: Aug. 6, 2020, 9:01 a.m.
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Listed in: Science

An Organotypic Mammary Duct Model Capturing Distinct Events of DCIS Progression

Published: Aug. 6, 2020, 7:02 a.m.
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Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

Published: Aug. 6, 2020, 6:01 a.m.
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CBX2 and CBX7 antagonistically regulate metabolic reprogramming in breast cancer

Published: Aug. 6, 2020, 5:03 a.m.
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Kinetics of Plasma cfDNA Predicts Clinical Response in Non-Small Cell Lung Cancer Patients

Published: Aug. 6, 2020, 5:02 a.m.
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STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

Published: Aug. 6, 2020, 5:02 a.m.
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Reprogramming of stromal fibroblasts by chemotherapy-induced secretion of IFNβ1 drives re-growth of breast cancer cells after treatment.

Published: Aug. 6, 2020, 2:02 a.m.
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Functional drug susceptibility testing based on biophysical measurements predicts patient outcome in glioblastoma patient-derived neurosphere models

Published: Aug. 6, 2020, 2:02 a.m.
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DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

Published: Aug. 6, 2020, 1:02 a.m.
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Listed in: Science

Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells

Published: Aug. 5, 2020, 6:02 a.m.
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Listed in: Science

CRISPRCas9 technology abolishes the BCRABL1 oncogene effect in chronic myeloid leukemia and restores normal hematopoiesis

Published: Aug. 5, 2020, 6:02 a.m.
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Listed in: Science

H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2

Published: Aug. 5, 2020, 5:01 a.m.
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Listed in: Science

Divergent use of metabolic fluxes in breast cancer metastasis

Published: Aug. 4, 2020, 11:01 p.m.
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Merkel cell polyomavirus in Merkel cell carcinoma: Integration sites and involvement of the KMT2D tumor suppressor gene

Published: Aug. 4, 2020, 7:05 p.m.
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Molecular Determinants of Prognosis and Evolution in Diffuse-Lower Grade Astrocytomas

Published: Aug. 4, 2020, 10:01 a.m.
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Ancestry Influences on the Molecular Presentation of Tumours

Published: Aug. 4, 2020, 9:01 a.m.
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Site-specific targeting of a light activated dCas9-KIllerRed fusion protein generates transient, localized regions of oxidative DNA damage.

Published: Aug. 4, 2020, 8:01 a.m.
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Listed in: Science

HDAC1 regulates the chromatin landscape to establish transcriptional dependencies in chronic lymphocytic leukemia

Published: Aug. 3, 2020, 5:01 p.m.
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Multi-organ signaling mobilizes tumor-associated erythroid cells expressing immune checkpoint molecules

Published: Aug. 3, 2020, 5:01 p.m.
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miR-100-5p downregulates mTOR to suppress the proliferation, migration and invasion of prostate cancer cells

Published: July 31, 2020, 9:01 a.m.
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Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

Published: July 31, 2020, 4:01 a.m.
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Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer

Published: July 30, 2020, 11:01 p.m.
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STIL a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancer

Published: July 30, 2020, 4:01 p.m.
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Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue

Published: July 30, 2020, 3:01 p.m.
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Signatures of neutral evolution in exponentially growing tumors: a theoretical perspective

Published: July 30, 2020, 10:02 a.m.
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Listed in: Science

PTPN11SHP2 negatively regulates growth in breast epithelial cells: implications on tumorigenesis

Published: July 30, 2020, 9:01 a.m.
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RIP140 inhibits glycolysis-dependent proliferation of cancer cells by regulating transcriptional crosstalk between hypoxia induced factor and p53

Published: July 30, 2020, 7:01 a.m.
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SAMHD1 promotes oncogene-induced replication stress

Published: July 29, 2020, 8:01 a.m.
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Listed in: Science

Deep Texture Representations as a Universal Encoder for Pan-cancer Histology

Published: July 29, 2020, 3:01 a.m.
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Neuroligin affects metastatic performance of CD66+ cells

Published: July 29, 2020, 2:03 a.m.
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High-resolution positron emission microscopy of patient-derived tumor organoids

Published: July 29, 2020, 2:02 a.m.
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Developing Small Molecules that Inhibit K-RasGTP Binding Based on New Affinity Measurements

Published: July 29, 2020, 1:04 a.m.
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Listed in: Science

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

Published: July 29, 2020, 1:04 a.m.
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Heterogeneity in signaling pathway activity within primary and between primary and metastatic breast cancer

Published: July 29, 2020, 1:04 a.m.
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CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors.

Published: July 29, 2020, 1:04 a.m.
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Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

Published: July 29, 2020, 1:04 a.m.
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Larger organ size caused by obesity is a mechanism for higher cancer risk.

Published: July 29, 2020, 1:04 a.m.
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PLEKHA4 Promotes Wntβ-catenin Signaling-Mediated G1S Transition and Proliferation in Melanoma

Published: July 29, 2020, 1:04 a.m.
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Listed in: Science

Tumor-stromal IL1β NFκB ESE3 Signal Axis Drives Pancreatic Cancer Fibrosis, Chemoresistance, Prognosis

Published: July 28, 2020, 5:18 p.m.
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Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer

Published: July 28, 2020, 5:18 p.m.
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BRN2 and MITF together impact AXL expression in melanoma.

Published: July 28, 2020, 6:01 a.m.
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Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

Published: July 28, 2020, 12:01 a.m.
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Phylogenetics analysis of TP53 gene in humans and its use in biosensors for breast cancer diagnosis

Published: July 26, 2020, 7:32 p.m.
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Identification of clinical combination therapies to induce durable responses in kidney cancers

Published: July 26, 2020, 7:32 p.m.
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Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

Published: July 26, 2020, 7:32 p.m.
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Cell-free DNA as a biomarker for prostate cancer: elevated concentration and decreased fragment size

Published: July 26, 2020, 7:32 p.m.
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Integrated metabolome and transcriptome analyses provide insight into colon cancer development by the gut microbiota

Published: July 25, 2020, 9:11 p.m.
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Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Published: July 25, 2020, 7:32 p.m.
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Listed in: Science

Single cell tracing reveals heterogeneous drug-, dose-, and time-dependent effects on cancer cell fates

Published: July 25, 2020, 7:32 p.m.
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Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Published: July 24, 2020, 9:12 p.m.
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G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

Published: July 24, 2020, 9:12 p.m.
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Listed in: Science

Efficiency of a Randomized Confirmatory Basket Trial Design Constrained to Control the False Positive Rate by Indication

Published: July 24, 2020, 9:12 p.m.
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A meta-analysis of clinical cases of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance

Published: July 24, 2020, 9:12 p.m.
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The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancer

Published: July 24, 2020, 9:12 p.m.
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Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer

Published: July 24, 2020, 9:12 p.m.
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Podoplanin drives dedifferentiation and amoeboid invasion of melanoma

Published: July 24, 2020, 9:12 p.m.
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Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

Published: July 24, 2020, 9:12 p.m.
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Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN

Published: July 24, 2020, 9:12 p.m.
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Differential Mast Cell Phenotypes in Benign versus Cancer Tissues and Prostate Cancer Oncologic Outcomes

Published: July 24, 2020, 9:11 p.m.
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Radiotherapy and chemotherapy alter migration of brain cancer cells before cell death

Published: July 24, 2020, 9:11 p.m.
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Phenotypic plasticity and partial EMT underlie local invasion and distant metastasis in colon cancer

Published: July 24, 2020, 9:11 p.m.
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Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

Published: July 23, 2020, 9:12 p.m.
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A novel role of MNT as a negative regulator of REL and the NF-κB pathway

Published: July 22, 2020, 9:13 p.m.
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New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancer

Published: July 22, 2020, 9:13 p.m.
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Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

Published: July 22, 2020, 9:13 p.m.
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Listed in: Science

Analyzing the tumor microbiome to predict cancer patient survival and drug response

Published: July 22, 2020, 9:13 p.m.
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Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells

Published: July 21, 2020, 9:13 p.m.
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Plexin-B1 mutation drives prostate cancer metastasis

Published: July 21, 2020, 9:13 p.m.
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CENP-A overexpression drives distinct cell fates depending on p53 status

Published: July 21, 2020, 9:13 p.m.
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Dynamic multi-OMICs of glioblastoma reveal sensitivity to neddylation inhibition dependent on nuclear PTEN and DNA replication pathways

Published: July 21, 2020, 9:13 p.m.
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MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

Published: July 21, 2020, 9:13 p.m.
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Spliceosome-Associated MicroRNAs Identified in Breast Cancer Cells Act on Nuclear Targets and Are Potential Indicators for Tumorigenicity

Published: July 20, 2020, 9:14 p.m.
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Regression of Human Breast Carcinoma in Nude Mice After Adsflt Gene Therapy is Mediated by Tumor Vascular Endothelial Cell Apoptosis

Published: July 19, 2020, 9:14 p.m.
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RNA-binding protein FXR1 drives cMYC translation by mRNA circularization through eIF4F recruitment in ovarian cancer

Published: July 19, 2020, 9:14 p.m.
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Metabolic profiles as putative predictors of relapse in pediatric brain tumour using direct surface and imaging mass spectrometry

Published: July 18, 2020, 9:14 p.m.
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PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGASSTING pathway activation within tumor-associated macrophages

Published: July 18, 2020, 9:14 p.m.
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Listed in: Science

Wnt-mediated interactions of tumor-initiating cells with a macrophage niche drive skin tumor formation

Published: July 17, 2020, 9:14 p.m.
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SEED-MEDIATED RNA INTERFERENCE OF ANDROGEN SIGNALING AND SURVIVAL NETWORKS INDUCES CELL DEATH IN PROSTATE CANCER CELLS

Published: July 17, 2020, 9:14 p.m.
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Listed in: Science