At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
The conference will represent a unique forum to discuss the most recent and unpublished findings on the basic biology of replication fork perturbation and repair as well as on our current understanding of how replicative stress drives cancer and aging. Session topics will include: Basic mechanisms at the replication fork, Replication-repair interface, Replication fork remodeling, Structural and single molecule analysis of replication/repair, Replication-transcription interface, Replication-recombination interface Chromatin, replication and genome maintenance, Difficult-to-replicate loci and telomers, Replication stress in cancer onset and therapy.Podcasts
O. Fernandez-Capetillo - Mechanisms of resistance to anticancer therapies
Published: June 30, 2016, 3:55 p.m.Duration: 22 minutes 58 seconds
Listed in: Science
S. Mirkin - Mechanisms of genome instability mediated by interstitial telomeric sequences
Published: June 30, 2016, 9:35 a.m.Duration: 21 minutes 35 seconds
Listed in: Science
I. Whitehouse - Coupling of gene enhancers and replication origins
Published: June 30, 2016, 6:55 a.m.Duration: 22 minutes 55 seconds
Listed in: Science
A. Constantinou - A FANCM protein interaction screen reveals a pyrimidine catabolism enzyme required to prevent cell-intrinsic DNA replication stress
Published: June 29, 2016, 9:20 a.m.Duration: 20 minutes 31 seconds
Listed in: Science
J. Berger - Structural mechanisms for initiating DNA replication
Published: June 29, 2016, 8 a.m.Duration: 23 minutes 59 seconds
Listed in: Science
W. Yang - Molecular gymnastics during DNA translesion synthesis
Published: June 29, 2016, 7:35 a.m.Duration: 24 minutes 44 seconds
Listed in: Science
P. Pasero - SAMHD1 processes stalled forks and links DNA replication stress to inflammation
Published: June 28, 2016, 3:20 p.m.Duration: 20 minutes 58 seconds
Listed in: Science
D. Cortez - ETAA1 regulates ATR to maintain genome stability during DNA replication
Published: June 28, 2016, 2:55 p.m.Duration: 21 minutes 29 seconds
Listed in: Science
T. Carr - Mechanisms of replication-associated genome rearrangement
Published: June 28, 2016, 2:30 p.m.Duration: 22 minutes 55 seconds
Listed in: Science
P. Knipscheer - How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?
Published: June 28, 2016, 9:25 a.m.Duration: 22 minutes 17 seconds
Listed in: Science
P. Burgers - The inner workings of the lagging strand maturation machinery
Published: June 28, 2016, 7:10 a.m.Duration: 22 minutes 17 seconds
Listed in: Science